Custom Synthesis - Our Expertise - SYNthesis med chem

SYNthesis has the infrastructure and expertise to conduct a full range of modern synthetic organic chemistry. Some examples include:

Focused libraries (H2L, LO and Scaffold Hopping)
Heterocyclic & hetero-aromatic chemistry
Natural products & Asymmetric synthetic chemistry
Reference compounds (from mg to 1 kg batches)
Milligram scale to kilo scale
Final target compounds (from mg to Kg)
Short chain peptides, cyclic-peptide and peptidomimetic chemistry (solution phase)
Stable isotope-labelled synthesis

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Avoralstat:

18 linear steps and 22 steps overall.
Literature route modified for higher efficiency
Final target achieved in gram quantities

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ABT-737:

Lengthy synthesis involving chiral building blocks
Final target achieved on multi-gram scale

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Canagliflozin:

Carbohydrate based chemistry requiring strictly anhydrous conditions

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GSK690693:

Lengthy, large scale chemistry
Construction of multiple heterocycles
Final target achieved on multi-gram scale

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Our other services

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Medicinal Chemistry

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Custom Synthesis

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Integrated Drug Discovery

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PROTACs & Molecular Glues

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Antibody Drug Conjugates

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Hit Discovery

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Protein Production & Structural Biology

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