Medicinal Chemistry - SYNthesis med chem

Unlock Innovative Solutions with Our Medicinal Chemistry Services

At SYNthesis Med Chem, we are dedicated to advancing drug discovery and development through our state-of-the-art medicinal chemistry services. Our passion for innovation and scientific excellence positions us as your strategic partner in the quest for transformative medicinal chemistry solutions.

Why Choose Us?

Expert Team

Our seasoned medicinal chemists bring a wealth of experience across various therapeutic areas and drug modalities, from traditional small molecules to proximity-inducing compounds such as PROTACs and molecular glues, ADCs, peptides (including cyclic peptides), PDCs, macrocycles, and nucleotides. With a commitment to advancing your projects, we ensure that our team stays at the forefront of the latest scientific developments and methodologies.

Customized Solutions

Understanding that every project is unique, we offer customizable services designed to meet your particular needs. Whether you are at the lead optimization stage or require new compound design, we tailor our approach to fit your specific objectives.

Cutting-Edge Technology

Utilizing advanced technologies and software for CADD and AIDD, we offer unique capabilities in compound design ahead of synthesis and with property evaluation at the appropriate stage. Our investment in innovation means better outcomes for your projects.

Collaborative Approach

We believe in fostering strong partnerships with our clients. By working closely with your team, we ensure alignment on goals, timelines, and deliverables, leading to successful project execution. Honest, open and regular (both formal and informal) communication is paramount in our approach.

Integrated Drug Discovery

Our medicinal chemists work seamlessly with our colleagues in protein science, structural biology, early discovery biology including biophysical screening (ASMS, SPR and DEL) and bio-functional assays (both in vitro and in vivo), CADD/AIDD, DMPK and pharmacology, process chemistry and CMC to deliver fully integrated drug discovery services under one roof.

Our Services

Hit Identification and Lead Optimization

We apply robust screening methodologies using a variety of industry-proven techniques (ASMS, DEL, crystal soaking, SPR) to identify promising leads, optimizing them for efficacy, selectivity, and pharmacokinetic properties (tier 1 DMPK assays are quickly and readily accessible to our Medicinal Chemistry team).

Structure-Activity Relationship (SAR) Studies

Our expert chemists conduct comprehensive SAR analyses to identify crucial structural modifications and chemical space that improves compound properties and performance.

Synthetic Route Design and Development

We specialize in designing efficient synthetic routes for complex molecules, ensuring a suitable balance between scalability, cost-effectiveness and in time supply.

Analytical and Purification Development

Our team develops and validates analytical methods for the characterization and quantitative analysis of your desired compounds, ensuring quality and compliance. With 24/7 access to prep HPLCs and SFCs in house, our team always deliver your compounds at the requested purity and on time.

Project Management

Our experienced medicinal chemists co-ordinate Discovery projects with our in house biology departments (or when agreed, with third party biology CROs) and ensure smooth collaboration & communication between teams of different core disciplines, to drive projects to the specified milestones.

Regulatory Support

Navigate the complexities of regulatory requirements with our expert guidance, ensuring your compounds meet all necessary standards for clinical development.

Success Stories

We take pride in our successful collaborations:

Case Study 1 – Flexible Resource Deployment

The client in this program is a small biotech with a limited internal chemistry capacity. They have taken an IP position across a privileged structure that can be used as an isostere in a number of marketed APIs. This program was conducted across multiple targets working from finished API to install the isostere. Read more.

Case Study 2 – HTL to candidate

The client in this program is a medium sized biotech with no internal chemistry capacity. Working from a few early hit compounds, the project involved lead generation, optimization and ultimately, selection of a development candidate. The project involved development of an inhibitor of an epigenetic target for treatment of cancer and inflammatory diseases. Read more.

Case Study 3 – Fully integrated service

The client in this program is a virtual biotech with no internal chemistry capacity. They have a clinical candidate which is protected by a use patent on a target but were looking to develop a back-up compound in clear IP space. The target for this program is a pseudokinase. The client was looking for an antagonist of the receptor. Read more.

Get Started Today

Are you ready to take your medicinal chemistry project to the next level?

At SYNthesis Med Chem, we are committed to helping businesses innovate and succeed. Chose us as your Discovery Chemistry partner.