Hit to Lead

In the hit to lead discovery phase synthetic and medicinal chemistry are key. Multiple rounds of synthesis and biological assessment of the compounds are required to determine where the initial hit can be modified to deliver the desired activity, selectivity and ADME properties.

“With world timezone coverage we are in a unique position to offer real time management of our chemistry team whilst providing management level updates at a time that suits our clients.”

Molecular modelling is often used to assist in the process where crystal structures or homology models of the protein of interest are available. An important parallel to this process is the development of a fast and reproducible synthesis of the cores under investigation.

With a background in kinase inhibitor drug discovery SYNthesis is adept at navigating through published IP to generate leads that are both active and selective and possess appropriate ADME profiles. Hit to lead projects would typically employ 6-10 full time bench chemists.